Dr. Caudell is the principal investigator for the Laboratory of Molecular Pathology, which researches bones marrow failure as the result of hematological malignancies.
Dr. Caudell uses a mouse model system built on nonrandom chromosomal translocations associated with leukemogenesis to understand how fusion genes influence the development of bone marrow stem cells during malignancy. He is interested in the bone marrow microenvironment and how its role influences the malignant transformation of hematopoietic cells. To address these issues, he works with genetically engineered mice that develop Myelodysplastic syndrome, acute leukemia, and myleofibrosis. Using these model systems allows for investigations into the role of hematopoietic progenitor cells including megakaryocytes, the cells that give rise to platelets. Through the use of genetically engineered mice, Dr. Caudell and his lab members can model important hematological diseases seen in people. By investigating the molecular pathogenesis of hematological malignancies in mice, he can understand more about normal hematopoiesis, as well as identify potential therapeutic targets for treatments to alleviate human suffering and death due to the burden of cancer.