Flagellar decision-making in Pseudomonas aeruginosa: Should I stay or should I go?
Dr. Barbara Kazmierczak
October 26 at 12:20pm in the Fralin Auditorium, Fralin Hall room 102
Hosted by Birgit Sharf
Barbara Kazmierczak, MD PhD, is a Professor of Medicine and Microbial Pathogenesis at Yale University. Her laboratory is interested in bacterial-host interactions, and uses the opportunistic pathogen Pseudomonas aeruginosa to probe how bacteria transition from environment to host, as well as the usually protective innate immune responses that follow infection. Dr. Kazmierczak received her B.A./M.S. in Biology and Biochemistry/Molecular Biology from the University of Chicago, then completed her Ph.D. in the Zinder laboratory at Rockefeller University and M.D. at Cornell Weill Medical College in NYC. She began working on Type 3 secretion system effectors of P. aeruginosa as an infectious diseases fellow at UCSF, and has continued studying host-pathogen interactions in her own lab at Yale since 2001.
The bacterial flagellum is a remarkable nano-machine that not only powers swimming, but also participates in bacterial swarming, surface attachment and mechano-sensing. The P. aeruginosa flagellum has unusual features that we have recently visualized in situ using cryo-electron tomography. How these might contribute to bacterial mechano-sensing will be the subject of this presentation.